Reactome | CFI [extracellular region]

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CFI [extracellular region] Show undefined attributes

catalystActivities	[CatalystActivity:10170102] serine-type endopeptidase activity of CFI [extracellular region]
compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-RNO-8852842] CFI:CFH,FHR3:iC3b [plasma membrane] - Rattus norvegicus [Complex:R-RNO-976770] CFI:CFH:C3b [extracellular region] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-977602] Complement factor I binds to MCP, CR1:C4b, C3b - Rattus norvegicus [Reaction:R-RNO-976810] Complement factor I binds to extracellular Factor H:C3b - Rattus norvegicus [Reaction:R-RNO-977359] Complement factor I binds to membrane-associated Factor H:C3b - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10147945
displayName	CFI [extracellular region]
hasComponent	[EntityWithAccessionedSequence:R-RNO-976782] CFI(19-335) [extracellular region] [EntityWithAccessionedSequence:R-RNO-976750] CFI(340-583) [extracellular region]
inDisease	false
inferredFrom	[Complex:R-HSA-976749] CFI [extracellular region] - Homo sapiens
maxDepth	2
name	CFI
producedByEvent	[Reaction:R-RNO-976743] Factor I inactivates plasma Factor H-bound C3b - Rattus norvegicus [Reaction:R-RNO-977615] Factor I inactivates MCP/CR1-bound C4b/C3b - Rattus norvegicus [Reaction:R-RNO-976801] Complement factor I complex formation - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-976749
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-RNO-976743] Factor I inactivates plasma Factor H-bound C3b [Reaction:R-RNO-977615] Factor I inactivates MCP/CR1-bound C4b/C3b [Reaction:R-RNO-976801] Complement factor I complex formation
(activeUnit)	[CatalystActivity:10147956] serine-type endopeptidase activity of CFI:CFH:C3b [extracellular region] [CatalystActivity:10148111] serine-type endopeptidase activity of CFI:CFH,FHR3:C3b [plasma membrane]
(input)	[Reaction:R-RNO-976810] Complement factor I binds to extracellular Factor H:C3b [Reaction:R-RNO-977602] Complement factor I binds to MCP, CR1:C4b, C3b [Reaction:R-RNO-977359] Complement factor I binds to membrane-associated Factor H:C3b
(hasComponent)	[Complex:R-RNO-976770] CFI:CFH:C3b [extracellular region] [Complex:R-RNO-8852842] CFI:CFH,FHR3:iC3b [plasma membrane] [Complex:R-RNO-981633] C4b-binding protein:Factor I [plasma membrane] [Complex:R-RNO-977599] CFI:CD46, CR1:C4b, C3b complexes [plasma membrane] [Complex:R-RNO-977365] CFI:CFH,FHR3:C3b [plasma membrane]
(physicalEntity)	[CatalystActivity:10170102] serine-type endopeptidase activity of CFI [extracellular region]
(inferredTo)	[Complex:R-HSA-976749] CFI [extracellular region]

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