Reactome | Factor I inactivates plasma Factor H-bound C3b

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Factor I inactivates plasma Factor H-bound C3b Show undefined attributes

catalystActivity	[CatalystActivity:10147956] serine-type endopeptidase activity of CFI:CFH:C3b [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10147958
displayName	Factor I inactivates plasma Factor H-bound C3b
eventOf	[Pathway:R-RNO-977606] Regulation of Complement cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-976743] Factor I inactivates plasma Factor H-bound C3b - Homo sapiens
input	[Complex:R-RNO-976770] CFI:CFH:C3b [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Factor I inactivates plasma Factor H-bound C3b
output	[EntityWithAccessionedSequence:R-RNO-976779] C3 [extracellular region] [EntityWithAccessionedSequence:R-RNO-976788] Cfh [extracellular region] [Complex:R-RNO-976749] CFI [extracellular region] [Complex:R-RNO-976805] iC3b [extracellular region]
precedingEvent	[Reaction:R-RNO-976810] Complement factor I binds to extracellular Factor H:C3b - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-976743
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-977606] Regulation of Complement cascade
(inferredTo)	[Reaction:R-HSA-976743] Factor I inactivates plasma Factor H-bound C3b

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