Reactome | RAS intrinsic GTPase activity hydrolyzes GTP to GDP

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RAS intrinsic GTPase activity hydrolyzes GTP to GDP Show undefined attributes

catalystActivity	[CatalystActivity:10212254] GTPase activity of p21 RAS:GTP [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10212256
displayName	RAS intrinsic GTPase activity hydrolyzes GTP to GDP
eventOf	[Pathway:R-RNO-5673001] RAF/MAP kinase cascade - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9649735] Intrinsic nucleotide exchange on RAS - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Homo sapiens
input	[Complex:R-RNO-109783] p21 RAS:GTP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	RAS intrinsic GTPase activity hydrolyzes GTP to GDP
output	[Complex:R-RNO-109796] p21 RAS:GDP [plasma membrane]
precedingEvent	[Reaction:R-RNO-9649735] Intrinsic nucleotide exchange on RAS - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9649736
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5673001] RAF/MAP kinase cascade
(precedingEvent)	[Reaction:R-RNO-9649735] Intrinsic nucleotide exchange on RAS
(inferredTo)	[Reaction:R-HSA-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP

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