Reactome | p21 RAS:GTP [plasma membrane]

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p21 RAS:GTP [plasma membrane] Show undefined attributes

catalystActivities	[CatalystActivity:10212254] GTPase activity of p21 RAS:GTP [plasma membrane]
compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-5624477] p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-9632904] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] - Rattus norvegicus [Complex:R-RNO-5218802] RASA1:p21 RAS:GTP:SPG [plasma membrane] - Rattus norvegicus [Complex:R-RNO-5672712] p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5624494] RAF1 binds p21 RAS:GTP - Rattus norvegicus [Reaction:R-RNO-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP - Rattus norvegicus [Reaction:R-RNO-8981355] RASA1 binds RAS:GTP - Rattus norvegicus [Reaction:R-RNO-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP - Rattus norvegicus [Reaction:R-RNO-9658253] RAS:GTP binds PI3K - Rattus norvegicus [Reaction:R-RNO-5658435] RAS GAPs bind RAS:GTP - Rattus norvegicus [Reaction:R-RNO-5674018] BRAP binds RAS:GTP - Rattus norvegicus [Reaction:R-RNO-170986] Ral-GDS binds to Ras-GTP - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10118107
displayName	p21 RAS:GTP [plasma membrane]
hasComponent	[SimpleEntity:R-ALL-29438] GTP [cytosol] [DefinedSet:R-RNO-9649715] mature p21 RAS [plasma membrane]
inDisease	false
inferredFrom	[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane] - Homo sapiens
maxDepth	3
name	p21 RAS:GTP
producedByEvent	[Reaction:R-RNO-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) - Rattus norvegicus [Reaction:R-RNO-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) - Rattus norvegicus [Reaction:R-RNO-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) - Rattus norvegicus [Reaction:R-RNO-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras - Rattus norvegicus [Reaction:R-RNO-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Rattus norvegicus [Reaction:R-RNO-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET - Rattus norvegicus [Reaction:R-RNO-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET - Rattus norvegicus [Reaction:R-RNO-5672965] RAS GEFs promote RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 - Rattus norvegicus [Reaction:R-RNO-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) - Rattus norvegicus [Reaction:R-RNO-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) - Rattus norvegicus [Reaction:R-RNO-9649735] Intrinsic nucleotide exchange on RAS - Rattus norvegicus [Reaction:R-RNO-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers - Rattus norvegicus [Reaction:R-RNO-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP - Rattus norvegicus [Reaction:R-RNO-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-1433471] Activation of RAS by p-KIT bound SOS1 - Rattus norvegicus [Reaction:R-RNO-2424477] SOS mediated nucleotide exchange of RAS (SHC) - Rattus norvegicus [Reaction:R-RNO-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 - Rattus norvegicus [Reaction:R-RNO-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange - Rattus norvegicus [Reaction:R-RNO-5218845] p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-109783
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-RNO-9632904] PDPK1:PIP3:pS, p-T410 PRKCZ:p21 RAS:GTP [plasma membrane] [Complex:R-RNO-5624478] p21 RAS:GTP:RAF1 [plasma membrane] [Complex:R-RNO-5624477] p21 RAS:GTP:p-S338,Y340,Y341-RAF1 [plasma membrane] [Complex:R-RNO-5624470] p21 RAS:GTP:p-S338-RAF1 [plasma membrane] [Complex:R-RNO-5218802] RASA1:p21 RAS:GTP:SPG [plasma membrane] [Complex:R-RNO-5672715] p21 RAS:GTP:'activator' RAFs:YWHAB dimer [plasma membrane] [Complex:R-RNO-5672712] p21RAS:GTP:activated RAF homo/heterodimers [plasma membrane] [Complex:R-RNO-5672729] p21 RAS:GTP:'activator' RAF:YWHAB dimer [plasma membrane] [Complex:R-RNO-5675414] p21RAS:GTP:activated RAF1 homo/heterodimer [plasma membrane] [Complex:R-RNO-8981350] p21 RAS:GTP:RASA1 [plasma membrane] [Complex:R-RNO-9658249] p21 RAS:GTP:PI3K [plasma membrane] [Complex:R-RNO-5658227] p21 RAS:GTP:RAS GAPs [plasma membrane] [Complex:R-RNO-5674003] p21 RAS:GTP:BRAP [plasma membrane] [Complex:R-RNO-5674005] p21 RAS:GTP:ub-BRAP [plasma membrane] [Complex:R-RNO-5675430] p21RAS:GTP:dephosphorylated RAF1 homo/heterodimer [plasma membrane] [Complex:R-RNO-5675412] p21RAS:GTP:p-S621 RAF1 homo/heterodimer [plasma membrane] [Complex:R-RNO-171020] Ras-GTP:RalGDS complex [plasma membrane]
(input)	[Reaction:R-RNO-5624494] RAF1 binds p21 RAS:GTP [Reaction:R-RNO-5672950] "Activator" RAF:YWHAB dimer binds RAS:GTP [Reaction:R-RNO-8981355] RASA1 binds RAS:GTP [Reaction:R-RNO-9649736] RAS intrinsic GTPase activity hydrolyzes GTP to GDP [Reaction:R-RNO-9658253] RAS:GTP binds PI3K [Reaction:R-RNO-5658435] RAS GAPs bind RAS:GTP [Reaction:R-RNO-5674018] BRAP binds RAS:GTP [Reaction:R-RNO-170986] Ral-GDS binds to Ras-GTP
(output)	[Reaction:R-RNO-1433471] Activation of RAS by p-KIT bound SOS1 [Reaction:R-RNO-210977] Sos-mediated nucleotide exchange of Ras (Tie2 receptor:Grb2:Sos) [Reaction:R-RNO-186834] SOS-mediated nucleotide exchange on RAS (PDGF receptor:GRB2:SOS) [Reaction:R-RNO-5218845] p-SPHK1 phosphorylates sphingosine to sphingosine 1-phosphate [Reaction:R-RNO-2424477] SOS mediated nucleotide exchange of RAS (SHC) [Reaction:R-RNO-2179407] SOS1-mediated nucleotide exchange of RAS (HB-EFG-initiated) [Reaction:R-RNO-392054] NCAM1:pFAK:Grb2:Sos-mediated nucleotide exchange of Ras [Reaction:R-RNO-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 [Reaction:R-RNO-8851877] RAS guanyl nucleotide exchange by SOS1 associated with RANBP9 and MET [Reaction:R-RNO-8851827] RAS guanyl nucleotide exchange by MET-bound GRB2:SOS1 [Reaction:R-RNO-8851899] RAS guanyl nucleotide exchange by SOS1 bound to GRB2, SCH1-2 and MET [Reaction:R-RNO-5672965] RAS GEFs promote RAS nucleotide exchange [Reaction:R-RNO-9607304] SOS1-mediated nucleotide exchange of RAS downstream of FLT3 [Reaction:R-RNO-177945] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:SHC1:GRB2:SOS1) [Reaction:R-RNO-177938] SOS1-mediated nucleotide exchange of RAS (EGF:EGFR:GRB2:SOS1) [Reaction:R-RNO-9649735] Intrinsic nucleotide exchange on RAS [Reaction:R-RNO-1306972] RAS guanyl nucleotide exchange mediated by SOS1 bound to GRB2 in complex with phosphorylated ERBB4:ERBB2 heterodimers [Reaction:R-RNO-5654402] Activated FGFR2:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-8941618] Activated FGFR2:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-RNO-5654618] Activated FGFR2:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-5654647] Activated FGFR3:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-5654413] Activated FGFR3:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-8941628] Activated FGFR3:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-RNO-5654600] Activated FGFR1:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-5654392] Activated FGFR1:p-FRS:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-8941623] Activated FGFR1:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-RNO-1168636] p-RasGRP1,3:DAG cause RAS to exchange GDP for GTP [Reaction:R-RNO-5654663] Activated FGFR4:p-FRS2:GRB2:SOS1 activates RAS nucleotide exchange [Reaction:R-RNO-8941613] Activated FGFR4:p-FRS:p-PTPN11 activates RAS nucleotide exchange [Reaction:R-RNO-5654426] Activated FGFR4:p-SHC1:GRB2:SOS1 activates RAS nucleotide exchange
(inferredTo)	[Complex:R-HSA-109783] p21 RAS:GTP [plasma membrane]
(physicalEntity)	[CatalystActivity:10212254] GTPase activity of p21 RAS:GTP [plasma membrane]

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