Reactome | PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11

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PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 Show undefined attributes

catalystActivity	[CatalystActivity:10210313] ubiquitin protein ligase activity of PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane]
category	transition
compartment	[Compartment:17947] peroxisomal membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10210315
displayName	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11
eventOf	[Pathway:R-RNO-9033241] Peroxisomal protein import - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11 - Homo sapiens
input	[Complex:R-RNO-9033521] PEX2:PEX10:PEX12:PEX5L:Ub:UBE2D1,2,3:PEX7:PEX13:PEX14 [peroxisomal membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11
output	[Complex:R-RNO-9033497] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 [peroxisomal membrane] [DefinedSet:R-RNO-1234120] UBE2D1,2,3 [cytosol]
precedingEvent	[Reaction:R-RNO-9033527] PEX2:PEX10:PEX12 binds PEX5L (in PEX5L:PEX7:PEX13:PEX14:PEX2:PEX10:PEX12) and Ub:UBE2D1,2,3 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9033485
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9033241] Peroxisomal protein import
(precedingEvent)	[Reaction:R-RNO-9033516] PEX2:PEX10:PEX12:Ub:PEX5L:PEX7:PEX13:PEX14 binds PEX1:PEX6:PEX26 and ZFAND6
(inferredTo)	[Reaction:R-HSA-9033485] PEX2:PEX10:PEX12 monoubiquitinates PEX5L at cysteine-11

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