Reactome | IL22:IL22RA1:JAK1 binds IL10RB:TYK2

Schema > Reaction > Entries

IL22:IL22RA1:JAK1 binds IL10RB:TYK2 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10199298
displayName	IL22:IL22RA1:JAK1 binds IL10RB:TYK2
eventOf	[Pathway:R-RNO-8854691] Interleukin-20 family signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 - Homo sapiens
input	[Complex:R-RNO-6784360] IL10RB:TYK2 [plasma membrane] [Complex:R-RNO-448411] IL22:IL22RA1:JAK1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	IL22:IL22RA1:JAK1 binds IL10RB:TYK2 IL10RB:TYK2 receptor complex binds IL22:IL22RA1:JAK1 receptor complex IL22RA1:IL22 binds IL10RB
output	[Complex:R-RNO-8854697] IL22:IL22RA1:JAK1:IL10RB:TYK2 [plasma membrane]
precedingEvent	[Reaction:R-RNO-448480] IL22 binds IL22RA1:JAK1 receptor complex - Rattus norvegicus [Reaction:R-RNO-8987223] IL10RB binds TYK2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8854645
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-RNO-8987042] IL22:IL22RA1:JAK1:IL10RB:TYK2 phosphorylates JAK1,TYK2
(inferredTo)	[Reaction:R-HSA-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2

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