Reactome | RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10207103] ubiquitin-protein transferase activity of RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-RNO-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10207098
displayName	RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
hasComponent	[DefinedSet:R-RNO-1234106] hydroxyPro-HIF-alpha [cytosol] [Complex:R-RNO-8956074] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8956082] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] - Homo sapiens
maxDepth	5
name	RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha
producedByEvent	[Reaction:R-RNO-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8956082
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[Reaction:R-RNO-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
(physicalEntity)	[CatalystActivity:10207103] ubiquitin-protein transferase activity of RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
(output)	[Reaction:R-RNO-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha
(inferredTo)	[Complex:R-HSA-8956082] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]

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