Reactome | VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha

Schema > Reaction > Entries

VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha Show undefined attributes

catalystActivity	[CatalystActivity:10207103] ubiquitin-protein transferase activity of RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10207105
displayName	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
eventOf	[Pathway:R-RNO-8951664] Neddylation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-9755303] 26S proteasome degrades HIFalpha - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:18276] protein ubiquitination
inferredFrom	[Reaction:R-HSA-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha - Homo sapiens
input	[Complex:R-RNO-8956082] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] [Complex:R-RNO-1234116] UBE2D1,2,3:Ubiquitin [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha
output	[Complex:R-RNO-8956079] ub-hydroxyPro-HIF-alpha:VHL:EloB:EloC:NEDD8-CUL2:RBX1:COMMDs:CCDC22:DCUN1D1,2,4,5 [cytosol] [DefinedSet:R-RNO-1234120] UBE2D1,2,3 [cytosol]
precedingEvent	[Reaction:R-RNO-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha - Rattus norvegicus
regulatedBy	[NegativeRegulation:10207106] Negative regulation by 'RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:UBXN7 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8956106
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8951664] Neddylation
(precedingEvent)	[BlackBoxEvent:R-RNO-9755303] 26S proteasome degrades HIFalpha
(inferredTo)	[Reaction:R-HSA-8956106] VHL:EloB,C:NEDD8-CUL2:RBX1 complex ubiquitinylates HIF-alpha

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