Reactome | hydroxyPro-HIF-alpha [cytosol]

Schema > DefinedSet > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-8956082] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha - Rattus norvegicus [Reaction:R-RNO-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10151558
displayName	hydroxyPro-HIF-alpha [cytosol]
hasMember	[EntityWithAccessionedSequence:R-RNO-1234149] Epas1 [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-1234131] Hif1a [cytosol] - Rattus norvegicus [EntityWithAccessionedSequence:R-RNO-1234129] Hif3a [cytosol] - Rattus norvegicus
inDisease	false
inferredFrom	[DefinedSet:R-HSA-1234106] hydroxyPro-HIF-alpha [cytosol] - Homo sapiens
maxDepth	2
name	hydroxyPro-HIF-alpha HIF-alpha with Hydroxylated Proline HIF1A, HIF2A, HIF3A with Hydroxyproline
schemaClass	DefinedSet
species	[Species:48895] Rattus norvegicus
stId	R-RNO-1234106

(input)	[Reaction:R-RNO-8956103] VHL:EloB,C:NEDD8-CUL2:RBX1 complex binds hydroxyprolyl-HIF-alpha [Reaction:R-RNO-1234183] Cytosolic VHL:EloB,C:CUL2:RBX1 binds hydroxyprolyl-HIF-alpha
(hasComponent)	[Complex:R-RNO-8956082] RBX1:NEDD8-CUL2:EloB,C:VHL:COMMDs:CCDC22:DCUN1D1,2,4,5:hydroxyPro-HIF-alpha [cytosol] [Complex:R-RNO-1234113] ub-hydroxyPro-HIF-alpha [cytosol] [Complex:R-RNO-1234125] hydroxyPro-HIF-alpha:VHL:EloB,C:CUL2:RBX1:LIMD1,AJUBA,WTIP:PHD2,3 [cytosol]
(inferredTo)	[DefinedSet:R-HSA-1234106] hydroxyPro-HIF-alpha [cytosol]