Reactome | IL12RB2:JAK2 [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-8983520] IL35:(IL12RB2:JAK2 dimer) [plasma membrane] - Rattus norvegicus [Complex:R-RNO-8983520] IL35:(IL12RB2:JAK2 dimer) [plasma membrane] - Rattus norvegicus [Complex:R-RNO-8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane] - Rattus norvegicus [Complex:R-RNO-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] - Rattus norvegicus
consumedByEvent	[BlackBoxEvent:R-RNO-8983519] IL35 binds IL12RB2:IL12RB2 receptor - Rattus norvegicus [BlackBoxEvent:R-RNO-8983519] IL35 binds IL12RB2:IL12RB2 receptor - Rattus norvegicus [BlackBoxEvent:R-RNO-6809140] IL35 binds IL-12RB2:IL6ST receptor - Rattus norvegicus [Reaction:R-RNO-447252] IL12RB1:TYK2 binds IL12RB2:JAK2 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10140981
displayName	IL12RB2:JAK2 [plasma membrane]
hasComponent	[EntityWithAccessionedSequence:R-RNO-447249] Il12rb2 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-1168889] Jak2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-8950039] IL12RB2:JAK2 [plasma membrane] - Homo sapiens
maxDepth	2
name	IL12RB2:JAK2
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8950039
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(input)	[BlackBoxEvent:R-RNO-6809140] IL35 binds IL-12RB2:IL6ST receptor [BlackBoxEvent:R-RNO-8983519] IL35 binds IL12RB2:IL12RB2 receptor [Reaction:R-RNO-447252] IL12RB1:TYK2 binds IL12RB2:JAK2
(hasComponent)	[Complex:R-RNO-6809138] IL35:IL6ST:JAK1:IL12RB2:JAK2 [plasma membrane] [Complex:R-RNO-8983520] IL35:(IL12RB2:JAK2 dimer) [plasma membrane] [Complex:R-RNO-8983989] IL35:IL27RA:JAK1:IL12RB2:JAK2 [plasma membrane] [Complex:R-RNO-8950052] IL12RB1:TYK2:IL12RB2:JAK2 [plasma membrane]
(inferredTo)	[Complex:R-HSA-8950039] IL12RB2:JAK2 [plasma membrane]

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