Reactome | Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

Schema > Reaction > Entries

Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter Show undefined attributes

catalystActivity	[CatalystActivity:10203610] histone H3K4 methyltransferase activity of H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10203612
displayName	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
eventOf	[Pathway:R-RNO-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8936621] Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter - Homo sapiens
input	2 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-RNO-8936615] H3K4me2-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter
output	2 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-RNO-8936620] H3K4me3-Nucleosome:GP1BA gene:RUNX1,MeR206,MeR210-RUNX1:CBFB:PRMT1:GATA1:ZFPM1:Core MLL complex:EP300:KAT2B [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8936621
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8936459] RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
(inferredTo)	[Reaction:R-HSA-8936621] Core MLL complex methylates H3K4Me2-Nucleosome at the GP1BA gene promoter

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