Reactome | SOAT1,2 transfer acyl group to CHOL forming CHEST

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SOAT1,2 transfer acyl group to CHOL forming CHEST Show undefined attributes

catalystActivity	[CatalystActivity:10202757] cholesterol O-acyltransferase activity of SOAT1,2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10202759
displayName	SOAT1,2 transfer acyl group to CHOL forming CHEST
eventOf	[Pathway:R-RNO-8964038] LDL clearance - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	SOAT1,2 transfer acyl group to CHOL forming CHEST
output	[SimpleEntity:R-ALL-8876704] CHEST [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-8876485] CHOL translocates from lysosome membrane to ER membrane - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8876696
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8964038] LDL clearance
(inferredTo)	[Reaction:R-HSA-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST

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