Reactome | LDL clearance

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LDL clearance Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10222931
displayName	LDL clearance
eventOf	[Pathway:R-RNO-8964043] Plasma lipoprotein clearance - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:357988] low-density lipoprotein particle clearance
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-171122] LDL + LDLR => LDL:LDLR complex - Rattus norvegicus [Reaction:R-RNO-171141] LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent) - Rattus norvegicus [Reaction:R-RNO-171059] LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane] - Rattus norvegicus [Reaction:R-RNO-171106] LDLR:LDL complex => LDLR + LDL - Rattus norvegicus [BlackBoxEvent:R-RNO-8876366] LDL translocates from endosome lumen to lysosome lumen - Rattus norvegicus [Reaction:R-RNO-8865667] LIPA hydrolyses sterol esters to sterols and fatty acids - Rattus norvegicus [Reaction:R-RNO-8876472] NPC2 binds CHOL - Rattus norvegicus [Reaction:R-RNO-8876484] NPC2 transfers CHOL to NPC1 - Rattus norvegicus [BlackBoxEvent:R-RNO-8876485] CHOL translocates from lysosome membrane to ER membrane - Rattus norvegicus [Reaction:R-RNO-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Rattus norvegicus [Reaction:R-RNO-6813720] NCEH1 hydrolyzes cholesterol esters - Rattus norvegicus [Reaction:R-RNO-171087] LDLR [endosome membrane] => LDLR [plasma membrane] - Rattus norvegicus [Reaction:R-RNO-6784734] PCSK9 binds LDLR - Rattus norvegicus [Reaction:R-RNO-9733403] PCSK9 binds PCSK9 inhibitors - Rattus norvegicus [Reaction:R-RNO-6784735] PCSK9:LDLR bind to Clathrin - Rattus norvegicus [Reaction:R-RNO-6784729] PCSK9:LDLR:Clathrin-coated vesicle transport from plasma membrane to endolysosome - Rattus norvegicus [BlackBoxEvent:R-RNO-6784738] Degradation of PCSK9:LDLR:Clathrin-coated vesicle - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-8964038] LDL clearance - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	LDL clearance
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8964038
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8964043] Plasma lipoprotein clearance
(inferredTo)	[Pathway:R-HSA-8964038] LDL clearance

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