Reactome | SOAT1,2 transfer acyl group to CHOL forming CHEST

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SOAT1,2 transfer acyl group to CHOL forming CHEST Show undefined attributes

authored	[InstanceEdit:8876698] Jassal, Bijay, 2016-06-16
catalystActivity	[CatalystActivity:8876719] cholesterol O-acyltransferase activity of SOAT1,2 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:70101] cytosol
created	[InstanceEdit:8876698] Jassal, Bijay, 2016-06-16
crossReference	[DatabaseIdentifier:11881023] Rhea:17729
dbId	8876696
displayName	SOAT1,2 transfer acyl group to CHOL forming CHEST
edited	[InstanceEdit:8876698] Jassal, Bijay, 2016-06-16
eventOf	[Pathway:R-HSA-8964038] LDL clearance - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8876731] CHEST translocates from ER membrane to lipid particle - Homo sapiens
input	[SimpleEntity:R-ALL-1500578] acyl-CoA [cytosol] [SimpleEntity:R-ALL-193384] CHOL [endoplasmic reticulum membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1482898] Characterization of two human genes encoding acyl coenzyme A:cholesterol acyltransferase-related enzymes [LiteratureReference:8876710] Molecular cloning and functional expression of human acyl-coenzyme A:cholesterol acyltransferase cDNA in mutant Chinese hamster ovary cells [LiteratureReference:8876702] Purification, cloning, and expression of a human enzyme with acyl coenzyme A: cholesterol acyltransferase activity, which is identical to liver carboxylesterase [LiteratureReference:8876697] Human acyl-CoA:cholesterol acyltransferase-1 in the endoplasmic reticulum contains seven transmembrane domains [LiteratureReference:8876705] Acyl-coenzyme A:cholesterol acyltransferases [LiteratureReference:8878943] Acyl-coenzyme A: cholesterol acyltransferase modulates the generation of the amyloid beta-peptide [LiteratureReference:8878928] ACAT1 regulates the dynamics of free cholesterols in plasma membrane which leads to the APP-?-processing alteration
modified	[InstanceEdit:11879863] Wright, Adam, 2024-03-11
name	SOAT1,2 transfer acyl group to CHOL forming CHEST
orthologousEvent	[Reaction:R-CEL-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Caenorhabditis elegans [Reaction:R-DME-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Drosophila melanogaster [Reaction:R-GGA-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Gallus gallus [Reaction:R-XTR-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Xenopus tropicalis [Reaction:R-DRE-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Danio rerio [Reaction:R-SSC-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Sus scrofa [Reaction:R-BTA-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Bos taurus [Reaction:R-CFA-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Canis familiaris [Reaction:R-RNO-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Rattus norvegicus [Reaction:R-MMU-8876696] SOAT1,2 transfer acyl group to CHOL forming CHEST - Mus musculus
output	[SimpleEntity:R-ALL-8876704] CHEST [endoplasmic reticulum membrane] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[BlackBoxEvent:R-HSA-8876485] CHOL translocates from lysosome membrane to ER membrane - Homo sapiens
releaseDate	2016-12-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8942662] D'Eustachio, Peter, 2016-10-19
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8876696
summation	[Summation:8876709] Excess cellular cholesterol (CHOL) is esterified and stored ...

Referrals

(hasEvent)	[Pathway:R-HSA-8964038] LDL clearance
(precedingEvent)	[BlackBoxEvent:R-HSA-8876731] CHEST translocates from ER membrane to lipid particle

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