Reactome | 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde

Schema > Reaction > Entries

2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde Show undefined attributes

catalystActivity	[CatalystActivity:10144457] hydroxyacid-oxoacid transhydrogenase activity of ADHFE1(1-?) [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144468
displayName	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
eventOf	[Pathway:R-RNO-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde - Homo sapiens
input	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-880041] HBUT [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde
output	[SimpleEntity:R-ALL-879997] 2HG [mitochondrial matrix] [SimpleEntity:R-ALL-880046] SUCCSA [mitochondrial matrix]
precedingEvent	[Reaction:R-RNO-880050] (S)-2-hydroxyglutarate + FAD => 2-oxoglutarate + FADH2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-880033
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-880009] Interconversion of 2-oxoglutarate and 2-hydroxyglutarate
(inferredTo)	[Reaction:R-HSA-880033] 2-oxoglutarate + 4-hydroxybutyrate <=> (R)-2-hydroxyglutarate + succinate semialdehyde

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