Reactome | HSD17B1 hydrogenates E1 to EST17b

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HSD17B1 hydrogenates E1 to EST17b Show undefined attributes

catalystActivity	[CatalystActivity:10144015] estradiol 17-beta-dehydrogenase [NAD(P)+] activity of HSD17B1 dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10144017
displayName	HSD17B1 hydrogenates E1 to EST17b
eventOf	[Pathway:R-RNO-193144] Estrogen biosynthesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21394] estrogen biosynthetic process
inferredFrom	[Reaction:R-HSA-804969] HSD17B1 hydrogenates E1 to EST17b - Homo sapiens
input	[SimpleEntity:R-ALL-193066] E1 [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	HSD17B1 hydrogenates E1 to EST17b Estrone is hydrogenated to estradiol
output	[SimpleEntity:R-ALL-193132] EST17b [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-RNO-193060] CYP19A1 hydroxylates ANDST to E1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-804969
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-193144] Estrogen biosynthesis
(inferredTo)	[Reaction:R-HSA-804969] HSD17B1 hydrogenates E1 to EST17b

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