Reactome | mRNP complex dissociates from cytosolic face of NPC

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mRNP complex dissociates from cytosolic face of NPC Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10109444
displayName	mRNP complex dissociates from cytosolic face of NPC
eventOf	[Pathway:R-RNO-159236] Transport of Mature mRNA derived from an Intron-Containing Transcript - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-450434] AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA - Rattus norvegicus [Reaction:R-RNO-450592] KSRP binds AU-rich element in 3' UTR of mRNA - Rattus norvegicus [Reaction:R-RNO-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs - Rattus norvegicus [Reaction:R-RNO-450517] Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA - Rattus norvegicus [Reaction:R-RNO-430021] PAN2-PAN3 complex partially deadenylates mRNA - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:4519] mRNA export from nucleus
inferredFrom	[Reaction:R-HSA-75098] mRNP complex dissociates from cytosolic face of NPC - Homo sapiens
input	[Complex:R-RNO-159259] NPC:NXF1:NXT1:EJC:CBC:mRNA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	mRNP complex dissociates from cytosolic face of NPC Release from the NPC and Disassembly of the mRNP
output	[Complex:R-RNO-159329] mRNA:CBC:EJC:POLDIP3 [cytosol] [Complex:R-RNO-157689] Nuclear Pore Complex (NPC) [nuclear envelope] [Complex:R-RNO-8849140] NXF1,2:NXT1 [cytosol]
precedingEvent	[BlackBoxEvent:R-RNO-75097] Transport of the export-competent mRNP complex through the NPC - Rattus norvegicus
regulatedBy	[Requirement:10109439] Requirement by 'Nuclear Pore Complex (NPC) [nuclear envelope]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-75098
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-159236] Transport of Mature mRNA derived from an Intron-Containing Transcript
(precedingEvent)	[Reaction:R-RNO-450434] AUF1(hnRNP D0) dimers bind AU-rich element in 3' UTR of mRNA [Reaction:R-RNO-450592] KSRP binds AU-rich element in 3' UTR of mRNA [Reaction:R-RNO-450400] ZFP36 (Tristetraproline, TTP) binds AU-rich elements in 3' UTR of target mRNAs [Reaction:R-RNO-450517] Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA [Reaction:R-RNO-430021] PAN2-PAN3 complex partially deadenylates mRNA
(inferredTo)	[Reaction:R-HSA-75098] mRNP complex dissociates from cytosolic face of NPC