Reactome | Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA

Schema > Reaction > Entries

Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10141831
displayName	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA
eventOf	[Pathway:R-RNO-450385] Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-450488] BRF1 Complex recruits RNA degradation activities - Rattus norvegicus [Reaction:R-RNO-450474] MK2 phosphorylates BRF1 - Rattus norvegicus [Reaction:R-RNO-450490] Protein Kinase B/Akt phosphorylates BRF1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-450517] Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA - Homo sapiens
input	[OtherEntity:R-ALL-450523] mRNA Transcript Targeted by BRF1 [cytosol] [EntityWithAccessionedSequence:R-RNO-450547] Zfp36l1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA
output	[Complex:R-RNO-450589] BRF1:mRNA Complex [cytosol]
precedingEvent	[Reaction:R-RNO-75098] mRNP complex dissociates from cytosolic face of NPC - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-450517
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-450385] Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
(precedingEvent)	[Reaction:R-RNO-450488] BRF1 Complex recruits RNA degradation activities [Reaction:R-RNO-450474] MK2 phosphorylates BRF1 [Reaction:R-RNO-450490] Protein Kinase B/Akt phosphorylates BRF1
(inferredTo)	[Reaction:R-HSA-450517] Butyrate Response Factor1 (BRF1) binds AU-rich element in 3' UTR of mRNA

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