Reactome | PGD decarboxylates 6-phospho-D-gluconate

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PGD decarboxylates 6-phospho-D-gluconate Show undefined attributes

catalystActivity	[CatalystActivity:10105414] phosphogluconate dehydrogenase (decarboxylating) activity of PGD dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10105416
displayName	PGD decarboxylates 6-phospho-D-gluconate
eventOf	[Pathway:R-RNO-71336] Pentose phosphate pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-71306] RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate - Rattus norvegicus [Reaction:R-RNO-71303] RPE dimers isomerise RU5P to XY5P - Rattus norvegicus [Reaction:R-RNO-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+ - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-71299] PGD decarboxylates 6-phospho-D-gluconate - Homo sapiens
input	[SimpleEntity:R-ALL-29366] NADP+ [cytosol] [SimpleEntity:R-ALL-29996] PDG [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PGD decarboxylates 6-phospho-D-gluconate 6-phospho-D-gluconate + NADP+ => D-ribulose 5-phosphate + CO2 + NADPH + H+
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29732] RU5P [cytosol]
precedingEvent	[Reaction:R-RNO-71296] PGLS hydrolyzes D-glucono-1,5-lactone 6-phosphate - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-71299
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-71336] Pentose phosphate pathway
(precedingEvent)	[Reaction:R-RNO-71306] RPIA isomerizes D-ribulose 5-phosphate to ribose 5-phosphate [Reaction:R-RNO-71303] RPE dimers isomerise RU5P to XY5P [Reaction:R-RNO-71682] glutathione (oxidized) + NADPH + H+ => 2 glutathione (reduced) + NADP+
(inferredTo)	[Reaction:R-HSA-71299] PGD decarboxylates 6-phospho-D-gluconate

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