Reactome | Cyclin E associated events during G1/S transition

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Cyclin E associated events during G1/S transition Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10221945
displayName	Cyclin E associated events during G1/S transition
eventOf	[Pathway:R-RNO-69206] G1/S Transition - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-69191] Formation of Cyclin E:Cdk2 complexes - Rattus norvegicus [Reaction:R-RNO-157906] Translocation of Cyclin E:Cdk2 complex to the nucleus - Rattus norvegicus [Reaction:R-RNO-187828] Translocation of p21 to the nucleus - Rattus norvegicus [Reaction:R-RNO-187506] Translocation of p27 to the nucleoplasm - Rattus norvegicus [Reaction:R-RNO-69562] Inactivation of Cyclin E:Cdk2 complexes by p27/p21 - Rattus norvegicus [Reaction:R-RNO-198613] AKT phosphorylates p21Cip1 and p27Kip1 - Rattus norvegicus [Pathway:R-RNO-187577] SCF(Skp2)-mediated degradation of p27/p21 - Rattus norvegicus [Reaction:R-RNO-69195] Phosphorylation of Cyclin E:CDK2 complexes by WEE1 - Rattus norvegicus [Reaction:R-RNO-69199] Dephosphorylation of Cyclin E:Cdk2 complexes by Cdc25A - Rattus norvegicus [Reaction:R-RNO-188350] CAK-mediated phosphorylation of Cyclin E:Cdk2 - Rattus norvegicus [Reaction:R-RNO-188386] Association of Rb with Cyclin E:Cdk2 complexes - Rattus norvegicus [Pathway:R-RNO-69200] Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Cyclin E associated events during G1/S transition
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-69202
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-69206] G1/S Transition
(inferredTo)	[Pathway:R-HSA-69202] Cyclin E associated events during G1/S transition

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