Reactome | AKT phosphorylates p21Cip1 and p27Kip1

Schema > Reaction > Entries

AKT phosphorylates p21Cip1 and p27Kip1 Show undefined attributes

catalystActivity	[CatalystActivity:10123336] protein serine/threonine kinase activity of p-T,p-S-AKT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10123361
displayName	AKT phosphorylates p21Cip1 and p27Kip1
eventOf	[Pathway:R-RNO-198323] AKT phosphorylates targets in the cytosol - Rattus norvegicus [Pathway:R-RNO-69202] Cyclin E associated events during G1/S transition - Rattus norvegicus [Pathway:R-RNO-69656] Cyclin A:Cdk2-associated events at S phase entry - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172430] phosphatidylinositol 3-kinase/protein kinase B signal transduction
inferredFrom	[Reaction:R-HSA-198613] AKT phosphorylates p21Cip1 and p27Kip1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-RNO-182504] CDKN1A,CDKN1B [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AKT phosphorylates p21Cip1 and p27Kip1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [DefinedSet:R-RNO-198605] p-T-CDKN1A/B [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-198613
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-69656] Cyclin A:Cdk2-associated events at S phase entry [Pathway:R-RNO-198323] AKT phosphorylates targets in the cytosol [Pathway:R-RNO-69202] Cyclin E associated events during G1/S transition
(inferredTo)	[Reaction:R-HSA-198613] AKT phosphorylates p21Cip1 and p27Kip1