Reactome | Complex I biogenesis

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Complex I biogenesis Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224841
displayName	Complex I biogenesis
eventOf	[Pathway:R-RNO-611105] Respiratory electron transport - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:262397] mitochondrial respiratory chain complex I assembly
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-5690023] NUBPL binds 4Fe-4S - Rattus norvegicus [BlackBoxEvent:R-RNO-6788523] NUBPL transfers 4Fe-4S to Complex I subunits - Rattus norvegicus [BlackBoxEvent:R-RNO-6788556] NUBPL transfers 4Fe-4S to NDUFV1, V2 - Rattus norvegicus [Reaction:R-RNO-6800868] NDUF subunits bind to form the IP subcomplex - Rattus norvegicus [Reaction:R-RNO-6799203] IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 - Rattus norvegicus [Reaction:R-RNO-6799178] Intermediate 1 binds HP subcomplex to form Intermediate 2 - Rattus norvegicus [Reaction:R-RNO-6799202] The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex - Rattus norvegicus [Reaction:R-RNO-6799197] ND4, ND5 bind the 550kDa complex to form the 815kDa complex - Rattus norvegicus [Reaction:R-RNO-6800870] NDUF subunits bind to form the FP subcomplex - Rattus norvegicus [Reaction:R-RNO-6799179] Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex - Rattus norvegicus [Reaction:R-RNO-6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-6799198] Complex I biogenesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Complex I biogenesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6799198
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-611105] Respiratory electron transport
(inferredTo)	[Pathway:R-HSA-6799198] Complex I biogenesis

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