Reactome | The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I

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The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I Show undefined attributes

category	dissociation
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10192902
displayName	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
eventOf	[Pathway:R-RNO-6799198] Complex I biogenesis - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-6799203] IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 - Rattus norvegicus [Reaction:R-RNO-6800870] NDUF subunits bind to form the FP subcomplex - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I - Homo sapiens
input	[Complex:R-RNO-6799183] 980kDa complex [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I
output	[Complex:R-RNO-6799192] Complex I [mitochondrial inner membrane] [Complex:R-RNO-5689052] MCIA complex [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-RNO-5689129] Ndufaf2 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-RNO-5689126] Ndufaf3 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-RNO-5689124] Ndufaf4 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-RNO-5689127] Ndufaf5 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-RNO-5689130] Ndufaf6 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-RNO-6788525] Ndufaf7 [mitochondrial matrix] [EntityWithAccessionedSequence:R-RNO-5689720] Timmdc1 [mitochondrial inner membrane]
precedingEvent	[Reaction:R-RNO-6799179] Peripheral arm subunits bind the 815kDa complex to form a 980kDa complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-6799196
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-6799198] Complex I biogenesis
(precedingEvent)	[Reaction:R-RNO-6799203] IP subcomplex binds NDUFAF3, NDUFAF4, TIMMDC1 to form Intermediate 1 [Reaction:R-RNO-6800870] NDUF subunits bind to form the FP subcomplex
(inferredTo)	[Reaction:R-HSA-6799196] The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I