Reactome | Association of RPA complexes with ssDNA at resected DNA DSBs

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Association of RPA complexes with ssDNA at resected DNA DSBs Show undefined attributes

category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10186370
displayName	Association of RPA complexes with ssDNA at resected DNA DSBs
eventOf	[Pathway:R-RNO-5693607] Processing of DNA double-strand break ends - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5684875] Binding of ATR:ATRIP to RPA at resected DNA DSBs - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Homo sapiens
input	[Complex:R-RNO-5684128] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm] [Complex:R-RNO-68462] RPA heterotrimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Association of RPA complexes with ssDNA at resected DNA DSBs
output	[Complex:R-RNO-5693552] RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1 [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5685994] Long-range resection of DNA DSBs by EXO1 or DNA2 - Rattus norvegicus [Reaction:R-RNO-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5693542
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-RNO-5684875] Binding of ATR:ATRIP to RPA at resected DNA DSBs
(inferredTo)	[Reaction:R-HSA-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs

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