Reactome | PPP4C:PPP4R2 dephosphorylates RPA2

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PPP4C:PPP4R2 dephosphorylates RPA2 Show undefined attributes

catalystActivity	[CatalystActivity:10184524] protein serine/threonine phosphatase activity of PPP4C:PPP4R2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10184526
displayName	PPP4C:PPP4R2 dephosphorylates RPA2
eventOf	[Pathway:R-RNO-5693607] Processing of DNA double-strand break ends - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5687758] PPP4C:PPP4R2 dephosphorylates RPA2 - Homo sapiens
input	[SimpleEntity:R-ALL-113518] H2O [nucleoplasm] [Complex:R-RNO-5685169] p-RPA heterotrimer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PPP4C:PPP4R2 dephosphorylates RPA2
output	[SimpleEntity:R-ALL-113550] Pi [nucleoplasm] [Complex:R-RNO-68462] RPA heterotrimer [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5687758
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-RNO-5693542] Association of RPA complexes with ssDNA at resected DNA DSBs
(inferredTo)	[Reaction:R-HSA-5687758] PPP4C:PPP4R2 dephosphorylates RPA2

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