Reactome | Activation of CHEK1 at resected DNA DSBs

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Activation of CHEK1 at resected DNA DSBs Show undefined attributes

catalystActivity	[CatalystActivity:10183857] protein serine/threonine kinase activity of ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10183859
displayName	Activation of CHEK1 at resected DNA DSBs
eventOf	[Pathway:R-RNO-5693607] Processing of DNA double-strand break ends - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5685230] CHEK1 phosphorylates RAD51 - Rattus norvegicus [Reaction:R-RNO-6799246] CHEK1 phosphorylates TP53 - Rattus norvegicus
goBiologicalProcess	[GO_BiologicalProcess:7962] DNA replication
inferredFrom	[Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-RNO-5684883] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1:TIMELESS:TIPIN:p-T916,S945-CLSPN:CHEK1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Activation of CHEK1 at resected DNA DSBs
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-RNO-5685162] ATR:ATRIP:p-RPA:3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:RAD17:RFC:RAD9:HUS1:RAD1:RHNO1:TOPBP1 [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-176296] phospho-Clspn [nucleoplasm] [EntityWithAccessionedSequence:R-RNO-113838] phospho-p-S317,S345-CHEK1 [nucleoplasm] [Complex:R-RNO-5684985] TIMELESS:TIPIN [nucleoplasm]
precedingEvent	[Reaction:R-RNO-5684882] CHEK1 is recruited to resected DNA DSBs - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5684887
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5693607] Processing of DNA double-strand break ends
(precedingEvent)	[Reaction:R-RNO-6799246] CHEK1 phosphorylates TP53 [Reaction:R-RNO-5685230] CHEK1 phosphorylates RAD51
(inferredTo)	[Reaction:R-HSA-5684887] Activation of CHEK1 at resected DNA DSBs