Reactome | Active NIK phosphorylates IKKA dimer

Schema > Reaction > Entries

Active NIK phosphorylates IKKA dimer Show undefined attributes

catalystActivity	[CatalystActivity:10177972] protein serine/threonine kinase activity of Active NIK [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10177974
displayName	Active NIK phosphorylates IKKA dimer
eventOf	[Pathway:R-RNO-5607761] Dectin-1 mediated noncanonical NF-kB signaling - Rattus norvegicus [Pathway:R-RNO-5676590] NIK-->noncanonical NF-kB signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5607722] Active NIK phosphorylates IKKA dimer - Homo sapiens
input	4 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-5607705] IKKA dimer [cytosol] [EntityWithAccessionedSequence:R-RNO-168189] Map3k14 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Active NIK phosphorylates IKKA dimer
output	[Complex:R-RNO-5607681] Active NIK:p-S176,180-IKKA dimer [cytosol] 4 × [SimpleEntity:R-ALL-29370] ADP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5607722
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5676590] NIK-->noncanonical NF-kB signaling [Pathway:R-RNO-5607761] Dectin-1 mediated noncanonical NF-kB signaling
(inferredTo)	[Reaction:R-HSA-5607722] Active NIK phosphorylates IKKA dimer

Cite Us!