Reactome | cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer

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cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181898
displayName	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
eventOf	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer - Homo sapiens
input	[Complex:R-RNO-5668435] cIAP1,2:TRAF2:TRAF3:NIK [cytosol] [Complex:R-RNO-5668423] TNFA trimer:TNFR2 trimer [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
output	[Complex:R-RNO-5668447] TNFA:TNFR2 heterotrimer:cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
precedingEvent	[Reaction:R-RNO-5668467] 2xTNFR2 binds TNFA trimer:TNFR2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5668417
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway
(precedingEvent)	[BlackBoxEvent:R-RNO-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK
(inferredTo)	[Reaction:R-HSA-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer

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