Reactome | 2xTNFR2 binds TNFA trimer:TNFR2

Schema > Reaction > Entries

2xTNFR2 binds TNFA trimer:TNFR2 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181910
displayName	2xTNFR2 binds TNFA trimer:TNFR2
eventOf	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5668467] 2xTNFR2 binds TNFA trimer:TNFR2 - Homo sapiens
input	[Complex:R-RNO-5668502] TNFA trimer:TNFR2 [plasma membrane] 2 × [EntityWithAccessionedSequence:R-RNO-5661484] Tnfrsf1b [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	2xTNFR2 binds TNFA trimer:TNFR2
output	[Complex:R-RNO-5668423] TNFA trimer:TNFR2 trimer [plasma membrane]
precedingEvent	[Reaction:R-RNO-5668404] TNFA binds TNFR2 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5668467
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5668541] TNFR2 non-canonical NF-kB pathway
(precedingEvent)	[Reaction:R-RNO-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer
(inferredTo)	[Reaction:R-HSA-5668467] 2xTNFR2 binds TNFA trimer:TNFR2

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