Reactome | NF1 is degraded by the proteasome

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NF1 is degraded by the proteasome Show undefined attributes

catalystActivity	[CatalystActivity:10103487] endopeptidase activity of 26S proteasome [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10181351
displayName	NF1 is degraded by the proteasome
eventOf	[Pathway:R-RNO-5658442] Regulation of RAS by GAPs - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-5658430] NF1 is degraded by the proteasome - Homo sapiens
input	[Complex:R-RNO-5658420] SPRED dimer:ub-NF1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	NF1 is degraded by the proteasome
output	[CandidateSet:R-RNO-5658219] SPRED dimer [plasma membrane]
precedingEvent	[Reaction:R-RNO-5658424] KBTBD7:CUL3:RBX1 ubiquitinates NF1 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5658430
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5658442] Regulation of RAS by GAPs
(inferredTo)	[BlackBoxEvent:R-HSA-5658430] NF1 is degraded by the proteasome

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