Reactome | PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]

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PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-5696681] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5651725] PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5691018] Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-6790468] Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5651828] PARG dePARylates PARP1,PARP2 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10180493
displayName	PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]
hasComponent	2 × [CandidateSet:R-RNO-5651712] PAR-PARP1,PAR-PARP2 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm] - Homo sapiens
maxDepth	3
name	PAR-PARP1,PAR-PARP2 dimers
producedByEvent	[Reaction:R-RNO-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB - Rattus norvegicus [Reaction:R-RNO-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate - Rattus norvegicus [Reaction:R-RNO-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5651709
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-RNO-5651828] PARG dePARylates PARP1,PARP2
(output)	[Reaction:R-RNO-5651739] PAR-PARP1,PAR-PARP2 dissociate from FEN1 and POLB [Reaction:R-RNO-5690988] 3'-incision of DNA by ERCC5 (XPG) in GG-NER [Reaction:R-RNO-5687653] PARP1,PARP2 dimers bound to MMEJ sites autoPARylate
(hasComponent)	[Complex:R-RNO-5651725] PAR-PARP1,PAR-PARP2:FEN1:POLB:SSB(3'poly-dNMP-displaced 5'ddRP-FLAP)-dsDNA [nucleoplasm] [Complex:R-RNO-5690214] GG-NER incision complex:5'-incised damaged DNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-RNO-5691059] GG-NER incision complex:5'-incised damaged DNA [nucleoplasm] [Complex:R-RNO-6790517] Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-RNO-6790468] Ub,SUMO:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1, PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-RNO-5691018] Ub:XPC:RAD23:CETN2:Open bubble-dsDNA:PAR-UV-DDB:TFIIH Core:XPA:PAR-PARP1,PAR-PARP2:CHD1L [nucleoplasm] [Complex:R-RNO-5696681] Ub:XPC:RAD23:CETN2:Distorted dsDNA:PAR-UV-DDB:PAR-PARP1,PAR-PARP2 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-5651709] PAR-PARP1,PAR-PARP2 dimers [nucleoplasm]

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