Reactome | H4c16 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9749196] H4K20Me2-nucleosome [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-9749196] H4K20Me2-nucleosome [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5651657] SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20) - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10104111
displayName	H4c16 [nucleoplasm]
endCoordinate	103
hasModifiedResidue	[ModifiedResidue:10104109] N6,N6-dimethyl-L-lysine at 21 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5651652] Me2K21-HIST1H4 [nucleoplasm] - Homo sapiens
maxDepth	1
name	H4c16 Me2K21-HIST1H4 P62804
producedByEvent	[Reaction:R-RNO-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20) - Rattus norvegicus
referenceEntity	[ReferenceGeneProduct:uniprot:P62804] UniProt:P62804 H4c2
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5651652
startCoordinate	2

(input)	[Reaction:R-RNO-5651657] SUV420H1, SUV420H2, (possibly SMYD3 (KMT3E)) methylate dimethyl-lysine-21 of histone H4 (H4K20)
(output)	[Reaction:R-RNO-5651654] SUV420H1 (KMT5B), SUV420H2 (KMT5C), (possibly SMYD3 (KMT3E)) methylate methyl-lysine-21 of histone H4 (H4K20)
(hasComponent)	[Complex:R-RNO-9749196] H4K20Me2-nucleosome [nucleoplasm] [Complex:R-RNO-5682998] K63PolyUb:K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm] [Complex:R-RNO-5682971] p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5651652] Me2K21-HIST1H4 [nucleoplasm]