Reactome | PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site

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PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site Show undefined attributes

authored	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:5649875] Orlic-Milacic, Marija, 2014-11-21
dbId	5649873
displayName	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
edited	[InstanceEdit:5654671] Orlic-Milacic, Marija, 2014-12-03
eventOf	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair - Homo sapiens
followingEvent	[Reaction:R-HSA-5649883] POLB-mediated DNA strand displacement synthesis - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-54745] FEN1 [nucleoplasm] [Complex:R-HSA-5649884] PARP1,PARP2 dimers [nucleoplasm] [Complex:R-HSA-5649885] POLB:APEX1:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:5649874] DNA polymerase beta -mediated long patch base excision repair. Poly(ADP-ribose)polymerase-1 stimulates strand displacement DNA synthesis [LiteratureReference:5649870] Photoaffinity labeling of mouse fibroblast enzymes by a base excision repair intermediate. Evidence for the role of poly(ADP-ribose) polymerase-1 in DNA repair [LiteratureReference:5649877] AP endonuclease and poly(ADP-ribose) polymerase-1 interact with the same base excision repair intermediate [LiteratureReference:5651851] PARP-2, A novel mammalian DNA damage-dependent poly(ADP-ribose) polymerase [LiteratureReference:5651857] Poly(ADP-ribose) polymerase null mouse cells synthesize ADP-ribose polymers [LiteratureReference:5651866] Functional interaction between PARP-1 and PARP-2 in chromosome stability and embryonic development in mouse [LiteratureReference:5651836] Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site
orthologousEvent	[Reaction:R-DDI-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Dictyostelium discoideum [Reaction:R-XTR-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Xenopus tropicalis [Reaction:R-DRE-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Danio rerio [Reaction:R-SSC-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Sus scrofa [Reaction:R-BTA-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Bos taurus [Reaction:R-CFA-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Canis familiaris [Reaction:R-RNO-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Rattus norvegicus [Reaction:R-MMU-5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - Mus musculus
output	[EntityWithAccessionedSequence:R-HSA-50119] APEX1 [nucleoplasm] [Complex:R-HSA-5649866] PARP1,PARP2:FEN1:POLB:SSB(3'dNMP-displaced 5'ddRP)-dsDNA [nucleoplasm]
precedingEvent	[Reaction:R-HSA-111253] POLB incorporates the first 3' dNMP and displaces 5'ddRP at SSB site - Homo sapiens
regulatedBy	[PositiveRegulation:R-HSA-8986540] Positive regulation by 'PARG [nucleoplasm]'
regulationReference	[RegulationReference:9642005] Positive regulation by 'PARG [nucleoplasm]' Poly(ADP-ribose) polymerase 1 accelerates single-strand break repair in concert with poly(ADP-ribose) glycohydrolase
releaseDate	2015-03-19
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:5673689] Borowiec, James, 2014-12-22
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-5649873
summation	[Summation:5651660] Homodimers and/or heterodimers of PARP1 and PARP2 bind singl...
updateTrackers	[UpdateTracker:9781113] Update Tracker - [Reaction:5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - v61:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9781113] Update Tracker - [Reaction:5649873] PARP1,PARP2 dimers and FEN1 bind POLB and displace APEX1 from damaged AP site - v61:[addRegulator]
(hasEvent)	[Pathway:R-HSA-110362] POLB-Dependent Long Patch Base Excision Repair
(precedingEvent)	[Reaction:R-HSA-5649883] POLB-mediated DNA strand displacement synthesis

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