Reactome | P4 bind PGR (in the HSP90 chaperone complex)

Schema > Reaction > Entries

P4 bind PGR (in the HSP90 chaperone complex) Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10214543
displayName	P4 bind PGR (in the HSP90 chaperone complex)
eventOf	[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9725885] P4 bind PGR (in the HSP90 chaperone complex) - Homo sapiens
input	[Complex:R-RNO-9725890] HSP90:ATP:FKBP4:PTGES3:PGR [cytosol] [SimpleEntity:R-ALL-193055] P4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	P4 bind PGR (in the HSP90 chaperone complex)
output	[Complex:R-RNO-9725883] HSP90:ATP:FKBP4:PTGES3:PGR:P4 [cytosol]
precedingEvent	[Reaction:R-RNO-5618073] FKBP4 replaces FKBP5 within HSP90:ATP:FKBP5:unfolded protein - Rattus norvegicus [Reaction:R-RNO-5618110] p23 (PTGES3) binds HSP90:ATP:FKBP4:nascent protein - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9725885
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3371497] HSP90 chaperone cycle for steroid hormone receptors (SHR) in the presence of ligand
(precedingEvent)	[BlackBoxEvent:R-RNO-5618080] HSP90:ATP:p23:FKBP52:SHR:SH translocates to the nucleus
(inferredTo)	[Reaction:R-HSA-9725885] P4 bind PGR (in the HSP90 chaperone complex)

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