Reactome | 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

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55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed Show undefined attributes

category	omitted
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10177473
displayName	55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
eventOf	[Pathway:R-RNO-5419276] Mitochondrial translation termination - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-5419281] MRRF binds 55S ribosome:mRNA:tRNA - Rattus norvegicus
inferredFrom	[BlackBoxEvent:R-HSA-5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed - Homo sapiens
input	[Complex:R-RNO-5419280] 55S ribosome:mRNA (UAA,UAG stop codon):peptidyl-tRNA:MTRF1L:GTP [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed
output	[Complex:R-RNO-9941870] 55S ribosome:mRNA (UAA,UAG stop codon):tRNA [mitochondrial inner membrane] [SimpleEntity:R-ALL-113525] GDP [mitochondrial matrix] [DefinedSet:R-RNO-9941873] MT-ATP6,MT-ATP8,MT-CO2,MT-CO3,MT-CYB,MT-ND1,MT-ND2,MT-ND3,MT-ND4,MT-ND4L,MT-ND5 [mitochondrial inner membrane] [DefinedSet:R-RNO-5432633] MTRF1L, ICT1 [mitochondrial matrix] [SimpleEntity:R-ALL-113548] Pi [mitochondrial matrix]
precedingEvent	[Reaction:R-RNO-5419264] MTRF1L (MTRF1a) or ICT1 binds stop codon in 55S ribosome:mRNA:peptidyl-tRNA - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5419271
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-5419276] Mitochondrial translation termination
(precedingEvent)	[Reaction:R-RNO-5419281] MRRF binds 55S ribosome:mRNA:tRNA
(inferredTo)	[BlackBoxEvent:R-HSA-5419271] 55S ribosome:MTRF1L hydrolyzes peptidyl-tRNA bond and GTP is hydrolyzed

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