Reactome | Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates

Schema > Reaction > Entries

Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates Show undefined attributes

catalystActivity	[CatalystActivity:10176187] misfolded protein binding activity of HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10176189
displayName	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
eventOf	[Pathway:R-RNO-3371511] HSF1 activation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-3371591] Trimerization of cytosolic HSF1 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates - Homo sapiens
input	[Complex:R-RNO-5324677] HSF1:HSP90:HDAC6:VCP:PTGES3 [cytosol] [OtherEntity:R-ALL-5324631] Ub-protein aggregates [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates
output	[Complex:R-RNO-5324663] HDAC6:VCP:protein aggregates [cytosol] [EntityWithAccessionedSequence:R-RNO-3371452] Hsf1 [cytosol] [DefinedSet:R-RNO-3371429] HSP90:HSP90 [cytosol] 2 × [EntityWithAccessionedSequence:R-RNO-265269] Ptges3 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-5324632
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3371511] HSF1 activation
(precedingEvent)	[Reaction:R-RNO-3371591] Trimerization of cytosolic HSF1
(inferredTo)	[Reaction:R-HSA-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates

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