Reactome | Trimerization of cytosolic HSF1

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Trimerization of cytosolic HSF1 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10171057
displayName	Trimerization of cytosolic HSF1
eventOf	[Pathway:R-RNO-3371511] HSF1 activation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-3371527] HSF1 trimer translocates to the nucleus - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-3371591] Trimerization of cytosolic HSF1 - Homo sapiens
input	3 × [EntityWithAccessionedSequence:R-RNO-3371452] Hsf1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Trimerization of cytosolic HSF1
output	[Complex:R-RNO-4793915] HSF1 trimer [cytosol]
precedingEvent	[Reaction:R-RNO-3371586] Dissociation of cytosolic HSF1:HSP90 complex - Rattus norvegicus [Reaction:R-RNO-5324632] Dissociation of cytosolic HSF1:HSP90:HDAC6:PTGES3 upon sensing protein aggregates - Rattus norvegicus
regulatedBy	[PositiveRegulation:10171058] Positive regulation by 'EEF1A1 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-3371591
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-3371511] HSF1 activation
(precedingEvent)	[BlackBoxEvent:R-RNO-3371527] HSF1 trimer translocates to the nucleus
(inferredTo)	[Reaction:R-HSA-3371591] Trimerization of cytosolic HSF1

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