Reactome | L1-EGFR trans-heterodimerization

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10140324
displayName	L1-EGFR trans-heterodimerization
eventOf	[Pathway:R-RNO-445144] Signal transduction by L1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-445069] L1-EGFR trans-heterodimerization - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-179837] EGFR [plasma membrane] [EntityWithAccessionedSequence:R-RNO-191465] L1cam [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	L1-EGFR trans-heterodimerization
output	[Complex:R-RNO-445016] L1-EGFR trans-heterodimer [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-445069
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-RNO-445144] Signal transduction by L1
(inferredTo)	[Reaction:R-HSA-445069] L1-EGFR trans-heterodimerization

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