Reactome | Energy dependent regulation of mTOR by LKB1-AMPK

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Energy dependent regulation of mTOR by LKB1-AMPK Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10223301
displayName	Energy dependent regulation of mTOR by LKB1-AMPK
eventOf	[Pathway:R-RNO-165159] MTOR signalling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:171508] regulation of cell cycle
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-RNO-380942] LKB1 forms a trimeric complex with STRAD and MO25 - Rattus norvegicus [Reaction:R-RNO-200421] Activation of cytosolic AMPK by phosphorylation - Rattus norvegicus [Reaction:R-RNO-380949] AMPK is dephosphorylated - Rattus norvegicus [Reaction:R-RNO-380930] Phosphorylated AMPK binds AMP - Rattus norvegicus [Reaction:R-RNO-447074] AMPK phosphorylates Raptor in the mTORC1 complex - Rattus norvegicus [Reaction:R-RNO-380927] p-AMPK phosphorylates TSC1:TSC2 - Rattus norvegicus [Reaction:R-RNO-380979] RHEB in mTORC1:RHEB:GTP hydrolyses GTP - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Energy dependent regulation of mTOR by LKB1-AMPK
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-380972
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-RNO-5628897] TP53 Regulates Metabolic Genes
(hasEvent)	[Pathway:R-RNO-165159] MTOR signalling
(inferredTo)	[Pathway:R-HSA-380972] Energy dependent regulation of mTOR by LKB1-AMPK

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