Reactome | Translocation of active caspase-8 to the mitochondrial membrane

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Translocation of active caspase-8 to the mitochondrial membrane Show undefined attributes

category	transition
compartment	[Compartment:70101] cytosol [Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10129739
displayName	Translocation of active caspase-8 to the mitochondrial membrane
eventOf	[Pathway:R-RNO-75153] Apoptotic execution phase - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-351894] Caspase mediated cleavage of BAP31 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-351863] Translocation of active caspase-8 to the mitochondrial membrane - Homo sapiens
input	[Complex:R-RNO-2562550] active caspase-8 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Translocation of active caspase-8 to the mitochondrial membrane
output	[Complex:R-RNO-2671818] active caspase-8 [mitochondrial outer membrane]
precedingEvent	[Reaction:R-RNO-2562564] Caspase-8 processing within TLR4 complex - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-351863
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-75153] Apoptotic execution phase
(precedingEvent)	[Reaction:R-RNO-351894] Caspase mediated cleavage of BAP31
(inferredTo)	[Reaction:R-HSA-351863] Translocation of active caspase-8 to the mitochondrial membrane

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