Reactome | active caspase-8 [cytosol]

Schema > Complex > Entries

catalystActivities	[CatalystActivity:10113335] cysteine-type endopeptidase activity of active caspase-8 [cytosol] [CatalystActivity:10215138] cysteine-type peptidase activity of active caspase-8 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-RNO-5660654] MALT1:active caspase-8 [cytosol] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-5660665] Caspase-8 binds MALT - Rattus norvegicus [Reaction:R-RNO-351863] Translocation of active caspase-8 to the mitochondrial membrane - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10113334
displayName	active caspase-8 [cytosol]
hasComponent	2 × [Complex:R-RNO-139950] Caspase-8 dimer [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5660651] active caspase-8 [cytosol] - Homo sapiens [Complex:R-HSA-2562550] active caspase-8 [cytosol] - Homo sapiens
maxDepth	3
name	active caspase-8
negativelyRegulates	[NegativeRegulation:10215145] Negative regulation by 'active caspase-8 [cytosol]'
producedByEvent	[Reaction:R-RNO-2562564] Caspase-8 processing within TLR4 complex - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2562550
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(activeUnit)	[CatalystActivity:10181386] cysteine-type endopeptidase activity of MALT1 oligomers:active caspase-8:ASC [cytosol]
(inferredTo)	[Complex:R-HSA-5660651] active caspase-8 [cytosol] [Complex:R-HSA-2562550] active caspase-8 [cytosol]
(input)	[Reaction:R-RNO-5660665] Caspase-8 binds MALT [Reaction:R-RNO-351863] Translocation of active caspase-8 to the mitochondrial membrane
(hasComponent)	[Complex:R-RNO-5660654] MALT1:active caspase-8 [cytosol]
(physicalEntity)	[CatalystActivity:10113335] cysteine-type endopeptidase activity of active caspase-8 [cytosol] [CatalystActivity:10215138] cysteine-type peptidase activity of active caspase-8 [cytosol]
(output)	[Reaction:R-RNO-2562564] Caspase-8 processing within TLR4 complex
(regulator)	[NegativeRegulation:10215145] Negative regulation by 'active caspase-8 [cytosol]'