Reactome | Pias4 [nucleoplasm]

Schema > EntityWithAccessionedSequence > Entries

Pias4 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10168761] SUMO transferase activity of PIAS4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-RNO-5684058] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5683079] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] - Rattus norvegicus [Complex:R-RNO-5682590] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-3968362] SUMOylation of PIAS4 with SUMO1 - Rattus norvegicus [Reaction:R-RNO-5682586] HERC2 and PIAS4 are recruited to DNA DSBs - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10104132
displayName	Pias4 [nucleoplasm]
endCoordinate	510
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-2993789] PIAS4 [nucleoplasm] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-RNO-2997694] PIAS1,4 [nucleoplasm] - Rattus norvegicus [DefinedSet:R-RNO-9610513] PIAS2-2,PIAS3,PIAS4 [nucleoplasm] - Rattus norvegicus
name	Pias4 PIAS4 B5DFF9
referenceEntity	[ReferenceGeneProduct:uniprot:B5DFF9] UniProt:B5DFF9
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2993789
startCoordinate	2

Referrals

(input)	[Reaction:R-RNO-3968362] SUMOylation of PIAS4 with SUMO1 [Reaction:R-RNO-5682586] HERC2 and PIAS4 are recruited to DNA DSBs
(hasMember)	[DefinedSet:R-RNO-2997694] PIAS1,4 [nucleoplasm] [DefinedSet:R-RNO-9610513] PIAS2-2,PIAS3,PIAS4 [nucleoplasm] [DefinedSet:R-RNO-3465556] PIAS1,3,4 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10168761] SUMO transferase activity of PIAS4 [nucleoplasm]
(activeUnit)	[CatalystActivity:10183628] SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] [CatalystActivity:10183325] SUMO transferase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm]
(hasComponent)	[Complex:R-RNO-5684058] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [Complex:R-RNO-5683079] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [Complex:R-RNO-5682861] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [Complex:R-RNO-5682623] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] [Complex:R-RNO-5682609] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] [Complex:R-RNO-5682599] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] [Complex:R-RNO-5682590] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-2993789] PIAS4 [nucleoplasm]

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