Reactome | PIAS4 [nucleoplasm]

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PIAS4 [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-HSA-5684058] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-5683079] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] - Homo sapiens [Complex:R-HSA-5682590] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] - Homo sapiens
consumedByEvent	[Reaction:R-HSA-3968362] SUMOylation of PIAS4 with SUMO1 - Homo sapiens [Reaction:R-HSA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs - Homo sapiens
created	[InstanceEdit:2993794] May, B, 2013-01-19
dbId	2993789
displayName	PIAS4 [nucleoplasm]
endCoordinate	510
inDisease	false
inferredTo	[EntityWithAccessionedSequence:R-MMU-2993789] PIAS4 [nucleoplasm] - Mus musculus [EntityWithAccessionedSequence:R-RNO-2993789] Pias4 [nucleoplasm] - Rattus norvegicus [EntityWithAccessionedSequence:R-CFA-2993789] PIAS4 [nucleoplasm] - Canis familiaris [EntityWithAccessionedSequence:R-BTA-2993789] PIAS4 [nucleoplasm] - Bos taurus [EntityWithAccessionedSequence:R-SSC-2993789] PIAS4 [nucleoplasm] - Sus scrofa [EntityWithAccessionedSequence:R-DRE-2993789] PIAS4 [nucleoplasm] - Danio rerio [EntityWithAccessionedSequence:R-XTR-2993789] pias4 [nucleoplasm] - Xenopus tropicalis [EntityWithAccessionedSequence:R-GGA-2993789] PIAS4 [nucleoplasm] - Gallus gallus [EntityWithAccessionedSequence:R-DME-2993789] Su(var)2-10 [nucleoplasm] - Drosophila melanogaster [EntityWithAccessionedSequence:R-CEL-2993789] PIAS4 [nucleoplasm] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-DDI-2993789] PIAS4 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-DDI-2993789-2] pisA [nucleoplasm] - Dictyostelium discoideum [DefinedSet:R-DDI-2993789-3] Homologues of PIAS4 [nucleoplasm] - Dictyostelium discoideum [EntityWithAccessionedSequence:R-SPO-2993789] PIAS4 [nucleoplasm] - Schizosaccharomyces pombe [EntityWithAccessionedSequence:R-SCE-2993789] PIAS4 [nucleoplasm] - Saccharomyces cerevisiae [EntityWithAccessionedSequence:R-SCE-2993789-2] PIAS4 [nucleoplasm] - Saccharomyces cerevisiae [DefinedSet:R-SCE-2993789-3] Homologues of PIAS4 [nucleoplasm] - Saccharomyces cerevisiae
maxDepth	1
memberOf	[DefinedSet:R-HSA-2997694] PIAS1,4 [nucleoplasm] - Homo sapiens [DefinedSet:R-HSA-9610513] PIAS2-2,PIAS3,PIAS4 [nucleoplasm] - Homo sapiens
modified	[InstanceEdit:4084885] Orlic-Milacic, M, 2013-07-31
name	PIAS4 E3 SUMO-protein ligase PIAS4 ecNumber6.3.2.-/ecNumber PIAS4_HUMAN PIASy PIASgamma
producedByEvent	[Reaction:R-HSA-5684071] RNF4 ubiquitinates MDC1 - Homo sapiens [Reaction:R-HSA-5693599] Association of Ku heterodimer with ends of DNA double-strand break - Homo sapiens
referenceEntity	[ReferenceGeneProduct:uniprot:Q8N2W9] UniProt:Q8N2W9 PIAS4
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:48887] Homo sapiens
stId	R-HSA-2993789
startCoordinate	2

Referrals

(input)	[Reaction:R-HSA-3968362] SUMOylation of PIAS4 with SUMO1 [Reaction:R-HSA-5682586] HERC2 and PIAS4 are recruited to DNA DSBs
(hasMember)	[DefinedSet:R-HSA-2997694] PIAS1,4 [nucleoplasm] [DefinedSet:R-HSA-9610513] PIAS2-2,PIAS3,PIAS4 [nucleoplasm] [DefinedSet:R-HSA-3465556] PIAS1,3,4 [nucleoplasm]
(physicalEntity)	[CatalystActivity:3215011] SUMO transferase activity of PIAS4 [nucleoplasm]
(output)	[Reaction:R-HSA-5693599] Association of Ku heterodimer with ends of DNA double-strand break [Reaction:R-HSA-5684071] RNF4 ubiquitinates MDC1
(hasComponent)	[Complex:R-HSA-5684058] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:SUMO2:K1840,p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [Complex:R-HSA-5683079] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [Complex:R-HSA-5682861] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4 [nucleoplasm] [Complex:R-HSA-5682623] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:PIAS4 [nucleoplasm] [Complex:R-HSA-5682609] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:PIAS4 [nucleoplasm] [Complex:R-HSA-5682599] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm] [Complex:R-HSA-5682590] DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm]
(activeUnit)	[CatalystActivity:5684057] SUMO transferase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-5S,2T-BRCA1-A complex [nucleoplasm] [CatalystActivity:5682610] SUMO transferase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:p-T4827-HERC2:PIAS4 [nucleoplasm]

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