Reactome | p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
componentOf	[Complex:R-RNO-2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] - Rattus norvegicus [Complex:R-RNO-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] - Rattus norvegicus
consumedByEvent	[Reaction:R-RNO-2730892] Recruitment of VAV to p-SLP-76 - Rattus norvegicus [Reaction:R-RNO-2424481] Recruitment of VAV and BTK to p-SLP-76 - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10166288
displayName	p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane]
hasComponent	[Complex:R-RNO-2424466] GADS:p-Y113,Y128,Y145-SLP-76 [cytosol] [Complex:R-RNO-2424468] p-5Y-LAT:p-SHC1:GRB2:SOS1 [plasma membrane] [DefinedSet:R-RNO-1169089] PLC gamma1,2 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane] - Homo sapiens
maxDepth	5
name	p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG
producedByEvent	[Reaction:R-RNO-2396594] Phosphorylation of SLP-76 by p-SYK - Rattus norvegicus [Reaction:R-RNO-2730851] Phosphorylation of SLP-76 by p-SYK - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2424460
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(hasComponent)	[Complex:R-RNO-2424469] p-5Y-LAT:PLCG1:GADS:p-3Y-SLP-76:BTK:p-VAV [plasma membrane] [Complex:R-RNO-2424457] p-5Y-LAT:GRB2:SOS1:GADS:p-3Y-SLP-76:PLCG:VAV:p-Y223,Y551-BTK [plasma membrane] [Complex:R-RNO-2424461] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG:VAV:BTK:PIP3 [plasma membrane] [Complex:R-RNO-2685683] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:TEC kinases:PIP3 [plasma membrane] [Complex:R-RNO-2685675] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-TEC kinases:PIP3 [plasma membrane] [Complex:R-RNO-2685650] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV:p-2Y-TEC kinases [plasma membrane] [Complex:R-RNO-2685668] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:VAV [plasma membrane] [Complex:R-RNO-2685666] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV [plasma membrane] [Complex:R-RNO-2685706] p-5Y-LAT:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG1:PIP3:p-VAV:RAC1-GTP [plasma membrane]
(input)	[Reaction:R-RNO-2424481] Recruitment of VAV and BTK to p-SLP-76 [Reaction:R-RNO-2730892] Recruitment of VAV to p-SLP-76
(output)	[Reaction:R-RNO-2396594] Phosphorylation of SLP-76 by p-SYK [Reaction:R-RNO-2730851] Phosphorylation of SLP-76 by p-SYK
(inferredTo)	[Complex:R-HSA-2424460] p-5Y-LAT:p-SHC1:GRB2:SOS1:GADS:p-Y113,Y128,Y145-SLP-76:PLCG [plasma membrane]

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