Reactome | SMURF1 binds phosphorylated PARD6A

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SMURF1 binds phosphorylated PARD6A Show undefined attributes

category	binding
compartment	[Compartment:204883] cell junction [Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10164263
displayName	SMURF1 binds phosphorylated PARD6A
eventOf	[Pathway:R-RNO-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2160935] SMURF1 ubiquitinates RHOA - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2160932] SMURF1 binds phosphorylated PARD6A - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-975972] Smurf1 [cytosol] [Complex:R-RNO-2134534] Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA [cell junction]
isInDisease	false
isInferred	true
maxDepth	1
name	SMURF1 binds phosphorylated PARD6A
output	[Complex:R-RNO-2160929] Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2160932
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
(precedingEvent)	[Reaction:R-RNO-2160935] SMURF1 ubiquitinates RHOA
(inferredTo)	[Reaction:R-HSA-2160932] SMURF1 binds phosphorylated PARD6A