Reactome | TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

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TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224393
displayName	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
eventOf	[Pathway:R-RNO-170834] Signaling by TGF-beta Receptor Complex - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:19282] transforming growth factor beta receptor signaling pathway
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-2160932] SMURF1 binds phosphorylated PARD6A - Rattus norvegicus [Reaction:R-RNO-2160935] SMURF1 ubiquitinates RHOA - Rattus norvegicus [BlackBoxEvent:R-RNO-2160931] Disassembly of tight junctions - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2173791
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-170834] Signaling by TGF-beta Receptor Complex
(inferredTo)	[Pathway:R-HSA-2173791] TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)

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