Reactome | Hyaluronan degradation

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Hyaluronan degradation Show undefined attributes

created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10224391
displayName	Hyaluronan degradation
eventOf	[Pathway:R-RNO-2142845] Hyaluronan metabolism - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:21629] hyaluronan catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-RNO-5693356] CEMIP hydrolyzes HA - Rattus norvegicus [BlackBoxEvent:R-RNO-9941055] SPAM1 randomly cleaves HA - Rattus norvegicus [Reaction:R-RNO-2160884] HA:HAR:HYAL2 binds to SLC9A1:p-CHP:Ca2+ - Rattus norvegicus [BlackBoxEvent:R-RNO-2160892] HYAL2 hydrolyses HA into 20kDa fragments - Rattus norvegicus [BlackBoxEvent:R-RNO-2160874] HYAL1 hydrolyses (HA)50 - Rattus norvegicus [Reaction:R-RNO-2162227] GUSB tetramer hydrolyses (HA)2 - Rattus norvegicus [Reaction:R-RNO-2162225] HEXA cleaves the terminal GlcNAc from small HA fragments - Rattus norvegicus [Reaction:R-RNO-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Rattus norvegicus [Reaction:R-RNO-2162226] GUSB tetramer hydrolyzes GlcA-?1,3-GlcNAc - Rattus norvegicus [Reaction:R-RNO-2162229] SLC17A5 exports GlcA from the lysosome to the cytosol - Rattus norvegicus
inferredFrom	[Pathway:R-HSA-2160916] Hyaluronan degradation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Hyaluronan degradation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2160916
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2142845] Hyaluronan metabolism
(inferredTo)	[Pathway:R-HSA-2160916] Hyaluronan degradation

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