Reactome | GUSB tetramer hydrolyses (HA)2

Schema > Reaction > Entries

GUSB tetramer hydrolyses (HA)2 Show undefined attributes

catalystActivity	[CatalystActivity:10158146] beta-glucuronidase activity of GUSB tetramer [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10164617
displayName	GUSB tetramer hydrolyses (HA)2
eventOf	[Pathway:R-RNO-2160916] Hyaluronan degradation - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-2162225] HEXA cleaves the terminal GlcNAc from small HA fragments - Rattus norvegicus [Reaction:R-RNO-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments - Rattus norvegicus [Reaction:R-RNO-2162229] SLC17A5 exports GlcA from the lysosome to the cytosol - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-2162227] GUSB tetramer hydrolyses (HA)2 - Homo sapiens
input	[Polymer:R-ALL-2160866] (HA)2 [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	GUSB tetramer hydrolyses (HA)2
output	[SimpleEntity:R-ALL-1678868] GlcA [lysosomal lumen] [OtherEntity:R-ALL-2162223] GlcNAc-GlcA-GlcNAc [lysosomal lumen]
precedingEvent	[BlackBoxEvent:R-RNO-2160874] HYAL1 hydrolyses (HA)50 - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-2162227
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-2160916] Hyaluronan degradation
(precedingEvent)	[Reaction:R-RNO-2162229] SLC17A5 exports GlcA from the lysosome to the cytosol [Reaction:R-RNO-2162225] HEXA cleaves the terminal GlcNAc from small HA fragments [Reaction:R-RNO-9638076] HEXB cleaves the terminal GlcNAc from small HA fragments
(inferredTo)	[Reaction:R-HSA-2162227] GUSB tetramer hydrolyses (HA)2