Reactome | ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]

Schema > Complex > Entries

compartment	[Compartment:876] plasma membrane
consumedByEvent	[Reaction:R-RNO-202168] Phosphorylation of ZAP-70 by Lck - Rattus norvegicus
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10125483
displayName	ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]
hasComponent	[Complex:R-RNO-203494] Antigen-bearing MHC Class II: TCR with phosphorylated ITAMs:CD4 [plasma membrane] [EntityWithAccessionedSequence:R-RNO-202397] ZAP70 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane] - Homo sapiens
maxDepth	7
name	ZAP-70 bound to phosphorylated ITAM motifs
producedByEvent	[Reaction:R-RNO-202344] Recruitment of ZAP-70 to phosphorylated ITAMs - Rattus norvegicus [Reaction:R-RNO-8855381] PTPN22 dephosphorylates ZAP70 - Rattus norvegicus
schemaClass	Complex
species	[Species:48895] Rattus norvegicus
stId	R-RNO-202330
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(output)	[Reaction:R-RNO-8855381] PTPN22 dephosphorylates ZAP70 [Reaction:R-RNO-202344] Recruitment of ZAP-70 to phosphorylated ITAMs
(input)	[Reaction:R-RNO-202168] Phosphorylation of ZAP-70 by Lck
(inferredTo)	[Complex:R-HSA-202330] ZAP-70 bound to phosphorylated ITAM motifs [plasma membrane]

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