Reactome | ALK dimerization

ALK dimerization

Stable Identifier

R-RNO-201531

Type

Reaction [binding]

Species

Rattus norvegicus

Compartment

plasma membrane

ReviewStatus

5/5

General

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SVG | | PPTX | SBGN

Studies with inducible dimerization constructs of rat ALK show that dimerization is required to activate downstream signaling cascades including PI3K/AKT, PLC gamma, MAP kinase and STAT pathways, among others (Gouzi et al, 2005; Stoica et al, 2001; Stoica et al, 2002).

Literature References

PubMed ID	Title	Journal	Year
12122009	Midkine binds to anaplastic lymphoma kinase (ALK) and acts as a growth factor for different cell types Stoica, GE, Kuo, AH, Powers, C, Bowden, ET, Sale, EB, Riegel, AT, Wellstein, A	J. Biol. Chem.	2002
16317043	Role of the subcellular localization of ALK tyrosine kinase domain in neuronal differentiation of PC12 cells Gouzi, JY, Moog-Lutz, C, Vigny, M, Brunet-de Carvalho, N	J Cell Sci	2005
11278720	Identification of anaplastic lymphoma kinase as a receptor for the growth factor pleiotrophin Stoica, GE, Kuo, AH, Aigner, A, Sunitha, I, Souttou, B, Malerczyk, C, Caughey, DJ, Wen, D, Karavanov, A, Riegel, AT, Wellstein, A	J Biol Chem	2001